Information Center
31
2023-05
Special Report on the Application of Molecular Diagnosis Filter Technology and Key Devices
On May 20, Huibo Optics was invited to host the 2023 China Life Sciences Conference "Molecular Biology Innovation and Development Forum". Deputy General Manager Gao Linlin delivered a special report on "Application of Optical Filter Technology and Key Devices in Molecular Diagnostics", which received widespread attention from industry professionals!
2023-05-31
31
2023-05
HuiBo Optics participated in the Japan OPIE 2023 exhibition.
From April 19 to 21, the OPIE and OPIC academic conferences on optoelectronics and lasers will be held concurrently in Yokohama, Japan.
2023-05-31
22
2015-10
Our country's large-size quartz glass optical uniformity has achieved a qualitative leap.
The China National Building Materials Science Research Institute has successfully developed large-sized quartz glass products, with a product diameter reaching over 600 millimeters and optical uniformity achieving 2.1×10-6, filling a domestic gap and marking the successful entry of China's large-sized quartz glass optical uniformity into the "2.0" era, laying a technical foundation for the independent research and development of larger-sized high-uniformity quartz glass products. Optical uniformity characterizes the degree of non-uniformity of the refractive index within the material. If optical non-uniformity exists, light passing through the medium may experience phase differences, potentially causing the optical system to fail to achieve its intended function or even to operate normally. As an essential lens material for various high-precision optical systems, the optical uniformity of fused quartz glass directly affects the imaging quality of the optical system. Since the "Ninth Five-Year Plan," the China National Building Materials Science Research Institute has been committed to researching new processes, technologies, equipment, and related fundamental theories for high-uniformity quartz glass. During the "Tenth Five-Year Plan" period, it pioneered the vertical chemical vapor deposition process in China, making the manufacturing of large-sized, high-uniformity quartz glass possible; during the "Eleventh Five-Year Plan" period, it achieved an optical uniformity of 3×10-6 for a diameter of 300 millimeters and could produce it in batches; through technological breakthroughs during the "Twelfth Five-Year Plan," optical uniformity improved from 3×10-6 to 2×10-6, achieving a qualitative leap, forming a complete set of technologies and equipment with independent intellectual property rights, and won the second prize in the scientific and technological invention category of the building materials industry in 2014, promoting industry progress, with related products applied in high-precision surveying camera systems and other high-tech fields.
2015-10-22
22
2015-10
Our country's large-size quartz glass optical uniformity has achieved a qualitative leap.
The China National Building Material Science Research Institute has successfully developed large-sized quartz glass products, with a product diameter of over 600 millimeters and optical uniformity reaching 2.1×10-6, filling a domestic gap.
2015-10-22
19
2015-08
The first portable DNA sequencing device is launched, only the size of a laptop.
When it comes to DNA testing, I believe everyone's first reaction is that it is complex, cumbersome, and requires professional equipment. Currently, ordinary DNA sequencing devices require extremely high computing power, and the instruments are very large and specialized. Recently, researchers at the University of Orlando in New Zealand have developed a wireless DNA sequencing device that is only the size of a regular laptop. This device, called "Freedom4," uses quantitative polymerase chain reaction technology to sequence DNA samples. It is worth mentioning that the battery life of this Freedom4 can reach 6 hours, and it can connect directly to smartphones or laptops via a built-in wireless module to transmit sequencing data in real-time, using a custom application for DNA analysis. In addition to complex DNA sequencing, this Freedom4 device can also perform clinical diagnostics for various acute diseases. In the future, it may even be applied to forensic testing and environmental monitoring work. Currently, the prospects for Freedom4 look very promising, as the device can analyze DNA samples not only from humans but also from poultry and other animals. Its small size and portability make it convenient for veterinarians to collect and analyze samples on farms, allowing for immediate assessment of the health of poultry and animals. At this stage, the Freedom4 device has already begun discussions with biotechnology companies.
2015-08-19
07
2015-05
GEN: Nanopore Sequencing - A New "Vanguard" for Infectious Disease Diagnosis
Assuming you are a doctor working with Doctors Without Borders in West Africa, a child with fever, headache, and fatigue is brought into your clinic. Based on the local environment and season, the most likely diagnoses would be malaria or Ebola. However, neither of these diseases offers a positive prognosis for the patient. The Ebola virus can spread quickly to others, necessitating the rapid isolation of the patient. In this situation, the time and accuracy of diagnosis are extremely important. The panic surrounding Ebola infection spreads faster than the disease itself. If your prognosis is incorrect, then any Ebola treatment will be completely ineffective. These distressing scenarios are faced by many doctors every day, not just in underdeveloped areas. Infectious diseases can easily spread through hospitals, schools, transportation, and other avenues. Although our current testing systems can relatively effectively isolate and identify these malignant microorganisms, there is always a welcome for faster and stronger partners in the field of diagnostic instruments. These new members not only have the ability to timely identify the causes of infectious disease outbreaks but can also identify the species of pathogens, drug resistance, and related genetic abnormalities. This information is invaluable to clinicians and public health workers. Technologies like PCR and ELISA analysis can provide accurate clinical assessments for infectious disease outbreaks, but many take several days. While the emergence of next-generation sequencing (NGS) platforms has filled the gap in diagnostic testing, NGS platforms face challenges not only with the time issues of most tests but also with the high costs of purchasing and operating the instruments. So, the question arises. Is there a technology that can provide a large amount of data related to infectious disease sources while being timely in operation? The answer is yes, this innovative technology is called nanopore sequencing. The Twisted Path of Nanopore Sequencing Nanopore sequencing is a relatively simple yet advanced technology capable of reading long fragments of natural DNA. In recent years, this technology has gradually come into the public eye, largely thanks to the sequencing device MinION from the UK company Oxford Nanopore Technologies. MinION is only 4 inches long, about the size of a standard USB drive, and consists of a sensor chip, dedicated integrated circuits, and a complete flow control system required for single-molecule sensing; it has an average read length of 80K bp and boasts a high sequencing speed. However, due to the low throughput of MinION, this device is more suitable for sequencing the genomes of bacteria and viruses or simple eukaryotes. In fact, despite the rapid rise in interest in nanopore sequencing technology among scientists and some companies in recent years, it is not a new concept. As early as 1995, renowned geneticist George Church from Harvard and MIT submitted the initial patent for nanopore devices. In the early stages, nanopore technology was not widely accepted, and many scientists even believed it was impossible to develop into an instrument capable of achieving the functions envisioned by dreamers. After many failed attempts, some scientists, including biochemistry professor David Deamer from the University of California, were able to measure the voltage changes as nucleotides passed through nanopore channels. Throughout the development of nanopore sequencing technology, there have been many skeptics who believe the biophysical concepts of the technology are flawed. Of course, optimists believe these issues are just difficult to solve, but not impossible. Through the collective efforts of these dreamers, nanopore sequencing has transformed from a makeshift device in academic laboratories into a valuable technological platform for broader use. New Forces on the Frontlines of Infectious Diseases Now, returning to the beginning of the article, we can see the rapid operation of nanopore sequencing in West Africa. It can not only quickly distinguish whether a patient is infected with the Ebola virus but also quickly identify the source of the virus. This is precisely the story of how the European Mobile Laboratory Project (EMLP) and the NIH brought nanopore sequencing to the frontlines of the Ebola outbreak this April. Using the MinION sequencer, the EMLP team determined the genomes of the Ebola virus infecting 14 patients within 48 hours. These research results helped clinicians diagnose Ebola patients and quickly identify the source of infection. Dr. Shawn Baker, CSO of AllSeq, said, "Nanopore sequencers have three main characteristics: speed, read length, and portability; these traits are very suitable for the infectious disease market." From the current application situation, nanopore sequencing has already been able to provide valuable data for hospital personnel on the frontlines of infectious diseases. So, can nanopore sequencing replace the current NGS systems? The answer is no. Although nanopore sequencing has achieved some positive results, there is still a significant need for improvement in its application range and accuracy. In March of this year, Oxford Nanopore Technologies announced that it has reopened the early trial program for the MinION sequencer, hoping to attract more users to participate.
2015-05-07
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